Here's a list of issues I've come across. While a lot of areas have improved the data in general for NPCs seems pretty messed up.
NPCs that should be stationary but aren't.
Ali the Snake Charmer
Drunk Ali
Various Bankers across the map
Missing NPC Spawns.
Melzars Maze - Everything.
Entrana - Everything. (It wasn't very accurate prior to this update either, but I've noticed the Fire Bird is missing now)
The Bear(s) south of the Varrock east mine.
Delrith south of Varrock for the Demon Slayer Quest. (I have completed the quest however, so this may be the issue.)
Black Demons in the Edgeville Slayer dungeon.
Gertrude from her house near Varrock.
The Gypsy from her tent in Varrock.
The Champions Guild is missing it's Guildmaster.
The Legends Guild is missing Siegfried Erkle. He would usually sell the Legends Cape and Shield Half.
Port Phasmatys is missings it's General Store owner.
Undead Cows, Undead Chickens and Alice's Ghostly Husband are missing from the farm near the Ectofuntus.
NPC citizens that turn into Warewolves are missing from Canifis.
Incorrect NPC Spawns.
There is an Evil Chicken spawn in the Champions Guild. I'm pretty sure this is an OSRS spawn.
There is a farmer in level 38 Wilderness called Edmond, I believe this is suppose to be a cape seller instead.
Ardougne Zoo has the Wilderness Cape seller Larry spawned.
Larry is also spawned off the coast of the eastern Rock Crab spot in Rellekka.
There are two Bankers standing outside of the Cooking Guild.
There are two Goblins spawned on the Eastern cliff of Goblin Village.
There are two Guards spawned in the Party Room.
There are Frogs and additional Giant Rats spawned all over Lumbridge Swamp.
There are additional Goblin Spawns near the Al Kharid gate.
There are additional Cow spawns in the Lumbridge Cow Pens.
There are additional Cows, Chickens and Goblins spawned south and north of the Lumbridge Windmill.
The Grand Exchange Bankers are spawned.
There seems to be additional Moss Giant spawns in the Varrock sewers.
There is a Captain Burnaby spawn West of Rimmington.
There is a Jelly spawn south of the Kurasks in the Relleka Slayer cave.
Party Pete is spawned in Falador instead of Camelot.
The Brimhaven Dungeon entrance contains a large number of Red Dragon spawns in the void.
Additionally, The King Black Dragon is no longer attackable nor aggressive. He only has an Examine option.